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Migraine headaches

by fioricetblog on April 8th, 2010
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migraine headache

More than 29.5 million Americans suffer from migraine, with women being affected three times more often than men. This vascular headache is most commonly experienced between the ages of 15 and 55, and 70% to 80% of sufferers have a family history of migraine. Less than half of all migraine sufferers have received a diagnosis of migraine from their healthcare provider. Migraine is often misdiagnosed as sinus headache or tension-type headache.

Many factors can trigger migraine attacks, such as alteration of sleep-wake cycle; missing or delaying a meal; medications that cause a swelling of the blood vessels; daily or near daily use of medications designed for relieving headache attacks; bright lights, sunlight, fluorescent lights, TV and movie viewing; certain foods; and excessive noise. Stress and/or underlying depression are important trigger factors that can be diagnosed and treated adequately.

Migraine characteristics can include:

  • Pain typically on one side of the head
  • Pain has a pulsating or throbbing quality
  • Moderate to intense pain affecting daily activities
  • Nausea or vomiting
  • Sensitivity to light or sound
  • Attacks last four to 72 hours, sometimes longer
  • Visual disturbances or aura
  • Exertion such as climbing stairs makes headache worse

Some people can tell when they are about to have a migraine because they see flashing lights or zigzag lines or they temporarily lose their vision.

Many things can trigger a migraine. These include

  • Anxiety
  • Stress
  • Lack of food or sleep
  • Exposure to light
  • Hormonal changes (in women)

Doctors used to believe migraines were linked to the opening and narrowing of blood vessels in the head. Now they believe the cause is related to genes that control the activity of some brain cells. Medicines can help prevent migraine attacks or help relieve symptoms of attacks when they happen. For many people, treatments to relieve stress can also help.

Approximately one-fifth of migraine sufferers experience aura, the warning associated with migraine, prior to the headache pain. Visual disturbances such as wavy lines, dots or flashing lights and blind spots begin from twenty minutes to one hour before the actual onset of migraine. Some people will have tingling in their arm or face or difficulty speaking. Aura was once thought to be caused by constriction of small arteries supplying specific areas of the brain. Now we know that aura is due to transient changes in the activity of specific nerve cells.

The pain of migraine occurs when excited brain cells trigger the trigeminal nerve to release chemicals that irritate and cause swelling of blood vessels on the surface of the brain. These swollen blood vessels send pain signals to the brainstem, an area of the brain that processes pain information. The pain of migraine is a referred pain that is typically felt around the eye or temple area. Pain can also occur in the face, sinus, jaw or neck area. Once the attack is full-blown, many people will be sensitive to anything touching their head. Activities such as combing their hair or shaving may be painful or unpleasant.

Diagnosis of migraine headache is made by establishing the history of the migraine-related symptoms and other headache characteristics as well as a family history of similar headaches. By definition, the physical examination of a patient with migraine headache in between the attacks of migraine does not reveal any organic causes for the headaches. Tests such as the CT scan and MRI are useful to confirm the lack of organic causes for the headaches.

There is currently no test to confirm the diagnosis of migraine.

Two important considerations when managing migraine
  1. Make sure the headache is a migraine and
  2. Restrict your use of acute migraine treatment to no more than 9 days per month. If you find that you need more acute medication than 9 days per month, then migraine prevention therapy is likely needed.  
Analgesics & NSAIDs
 
  • Nonspecific pain medications
  • Readily available as over-the-counter remedies (including aspirin, naproxen sodium, ibuprofen, acetaminophen, among others)
  • Cost affordable
  • May be given as monotherapy or in combination with other agents (eg. acetaminophen, aspirin, and caffeine)
  • Should not be used in patients who have contraindications for using NSAIDs (hyperacidity syndromes such as ulcer, gastrointestinal esophageal reflux disease, the triad of aspirin sensitivity, nasal polyps, and asthma and kidney disease)
  • Regular or even daily use of these medications may make headaches worse due to medication overuse
Ergotamine,
Ergot Combinations
Ergot Alkaloids (Dihydroergotamine)
 
  • There are currently several different formulations of ergotamine for the acute treatment of migraine including oral, rectal, or intranasal
  • Dihydroergotamine is available as an intranasal, intramuscular, or intravenous treatment
  • May work on more than just activated pathways in migraine
  • Nausea may be a side effect from these medications and also may be part of the migraine itself. Some patients may benefit in taking these agents with another medication to prevent nausea. 
Triptans
  • Readily available with prescription
  • Seven different triptans (almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan)
  • Available as oral tablets, orally disintegrating tablets, nasal sprays and subcutaneous injection, so you may request a specific formulation if you have a preference.
  • More migraine specific
  • Some patients may find improved response to triptans if they take their medication early in the course of the attack when pain is mild.
  • Common triptan side effects may include tingling, sleepiness, flushing, throat or chest tightness
 

From → Medication, Migraines

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